SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* Northpond Capital GP, LLC (Last) (First) (Middle) 7500 OLD GEORGETOWN ROAD SUITE 850 (Street) BETHESDA MD 20814 (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 10/07/2021	3. Issuer Name and Ticker or Trading Symbol IsoPlexis Corp [ ISO ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) Form filed by One Reporting Person X Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares
Series C Redeemable Convertible Preferred Stock	(1)	(1)	Common Stock	2,302,280	(1)	I	See footnote(2)
Series C-2 Redeemable Convertible Preferred Stock	(1)	(1)	Common Stock	2,473,048	(1)	I	See footnote(2)
Series D Redeemable Convertible Preferred Stock	(1)	(1)	Common Stock	1,528,864	(1)	I	See footnote(2)
Series D Redeemable Convertible Preferred Stock	(1)	(1)	Common Stock	1,040,048	(1)	I	See footnote(3)

1. Name and Address of Reporting Person* Northpond Capital GP, LLC (Last) (First) (Middle) 7500 OLD GEORGETOWN ROAD SUITE 850 (Street) BETHESDA MD 20814 (City) (State) (Zip)

1. Name and Address of Reporting Person* Northpond Capital, L.P. (Last) (First) (Middle) 7500 OLD GEORGETOWN ROAD SUITE 850 (Street) BETHESDA MD 20814 (City) (State) (Zip)

1. Name and Address of Reporting Person* Northpond Ventures GP, LLC (Last) (First) (Middle) 7500 OLD GEORGETOWN ROAD SUITE 850 (Street) BETHESDA MD 20814 (City) (State) (Zip)

1. Name and Address of Reporting Person* Northpond Ventures, LP (Last) (First) (Middle) 7500 OLD GEORGETOWN ROAD SUITE 850 (Street) BETHESDA MD 20814 (City) (State) (Zip)

1. Name and Address of Reporting Person* Rubin Michael P. (Last) (First) (Middle) C/O NORTHPOND VENTURES 7500 OLD GEORGETOWN ROAD, SUITE 850 (Street) BETHESDA MD 20814 (City) (State) (Zip)

Explanation of Responses:

1. Each share of the Series C Redeemable Convertible Preferred Stock, Series C-2 Redeemable Convertible Preferred Stock and Series D Redeemable Convertible Preferred Stock is convertible at any time, at the Reporting Persons' election, on a one-for-8 basis, and will convert automatically upon the Issuer's consummation of an initial public offering. The number of shares held is shown on an as-converted to common stock basis. The preferred stock has no expiration date.

2. The securities are held directly by Northpond Ventures, LP ("Northpond"). Northpond Ventures GP, LLC ("Northpond GP") is the general partner of Northpond. Michael P. Rubin ("Rubin") is the managing member of Northpond GP.

3. The securities are held directly by Northpond Capital, LP ("Northpond Capital"). Northpond Capital GP, LLC ("Northpond Capital GP") is the general partner of Northpond Capital. Rubin is the managing member of Northpond Capital GP.

Remarks:

	Northpond Capital GP, LLC, By: /s/ Patrick Smerkers, Senior Vice President, Finance and Operations	10/07/2021
	Northpond Capital, LP, By: Northpond Capital GP, LLC, its general partner, By: /s/ Patrick Smerkers, Senior Vice President, Finance and Operations	10/07/2021
	Northpond Ventures GP, LLC, By: /s/ Patrick Smerkers, Senior Vice President, Finance and Operations	10/07/2021
	Northpond Ventures, LP, By: Northpond Ventures GP, LLC, its general partner, By: /s/ Patrick Smerkers, Senior Vice President, Finance and Operations	10/07/2021
	/s/ Michael P. Rubin	10/07/2021
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
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