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                            July 16, 2021

       Sean Mackay
       Chief Executive Officer
       IsoPlexis Corporation
       35 NE Industrial Rd.
       Branford, CT 06405

                                                        Re: IsoPlexis
Corporation
                                                            Amendment No. 1 to
                                                            Draft Registration
Statement on Form S-1
                                                            Submitted July 2,
2021
                                                            CIK No. 0001615055

       Dear Mr. Mackay:

             We have reviewed your amended draft registration statement and
have the following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure.

              Please respond to this letter by providing the requested
information and either submitting
       an amended draft registration statement or publicly filing your
registration statement on
       EDGAR. If you do not believe our comments apply to your facts and
circumstances or do not
       believe an amendment is appropriate, please tell us why in your
response.

             After reviewing the information you provide in response to these
comments and your
       amended draft registration statement or filed registration statement, we
may have additional
       comments.

       Amendment No. 1 to Draft Registration Statement on Form S-1 submitted
July 2, 2021

       Management's Discussion and Analysis of Financial Condition and Results
of Operation
       Overview, page 59

   1.                                                   We note your response
to our prior comment 9. Please expand your disclosure in this
                                                        section to disclose
that you do not have supply agreements with certain suppliers
                                                        of critical components
and materials beyond purchase orders, as referenced on page 25.
 Sean Mackay
FirstName  LastNameSean Mackay
IsoPlexis Corporation
Comapany
July       NameIsoPlexis Corporation
     16, 2021
July 16,
Page  2 2021 Page 2
FirstName LastName
Business
Intellectual Property, page 87

2.       We note your response to our prior comment 19, which we reissue in
part. Please revise
         to disclose the scope of patent protection and products or processes
to which such patents
         relate for your issued patents. Please also revise to segregate patent
expiry for your issued
         patents and patent applications. Please also disclose the applicable
foreign jurisdictions for
         your issued patents. Please consider tabular disclosure in addition to
the narrative
         provided.
License Agreements, page 90

3.       We refer to your disclosure on page 90 relating to the additional
patent rights you licensed
         under the amended Yale Agreement in January 2018. Please expand your
disclosure to
         clearly identify the nature and scope of the patent rights that you
in-licensed. Please also
         revise your disclosure to include when the last-to-expire licensed
patent right under the
         Yale Agreement is scheduled to expire and the aggregate amounts paid
to date under the
         Yale Agreement.
4.       We refer to your disclosure on page 91 relating to your Caltech
Agreement. Please revise
         your disclosure to include when the last-to-expire licensed patent
right under the Caltech
         Agreement is scheduled to expire. Please also clarify whether there
are any potential
         future milestone payments.
       You may contact Jeanne Bennett at 202-551-3606 or Kevin Vaughn at
202-551-3494 if
you have questions regarding comments on the financial statements and related
matters. Please
contact Jane Park at 202-551-7439 or Christine Westbrook at 202-551-5019 with
any other
questions.



                                                                Sincerely,

                                                                Division of
Corporation Finance
                                                                Office of Life
Sciences
cc:      Matthew Jones, Esq.